I-Artemether CAS 71963-77-4 Isicatshulwa se-Artemisia Annua

I-Artemether yi-sesquiterpene lactone efumaneka kwiingcambu ze-I-Artemisia annua, eyaziwa ngokuba yi-sweet wormwood. Liyeza elinamandla lokulwa nemalariya elisetyenziselwa ukunyanga nokuthintela imalariya. I-Artemisinin, eyandulela i-artemether, yaqala ukukhutshwa kwesi sityalo ngeminyaka yoo-1970, kwaye ukufunyanwa kwayo kwanika umphandi waseTshayina uTu Youyou iMbasa yeNobel kwiNyango ngo-2015.

I-Artemether isebenza ngokutshabalalisa iiparasite ezibangela imalariya. Imalariya ibangelwa yiparasite yeprotozoan ebizwa ngokuba yiPlasmodium, edluliselwa ebantwini ngokulunywa ziingcongconi ze-Anopheles ezibhinqileyo ezineentsholongwane. Xa sele zingaphakathi kuluntu, iiparasite zanda ngokukhawuleza esibindini nakwiiseli ezibomvu zegazi, nto leyo ebangela umkhuhlane, ukugodola, kunye nezinye iimpawu ezifana nomkhuhlane. Ukuba ayinyangwa, imalariya inokubulala.

I-Artemether isebenza kakhulu kwiintlobo zePlasmodium falciparum ezingamelaniyo namayeza, ezibangela uninzi lwabantu ababulawa yimalariya kwihlabathi liphela. Isebenza nakwizinye iintlobo zeeparasite zePlasmodium ezibangela imalariya. I-Artemether idla ngokusetyenziswa kunye nezinye iziyobisi, ezifana ne-lumefantrine, ukunciphisa umngcipheko wokungamelani namayeza.

Ngaphandle kokusetyenziswa kwayo njengeyeza lokulwa nemalariya, i-artemether ikwafunyenwe inezinye iimpawu zonyango. Izifundo zibonise ukuba inemisebenzi yokulwa nokuvuvukala, ukulwa nomhlaza, kunye neyokulwa neentsholongwane. Isetyenziselwe ukunyanga isifo samathambo, i-lupus, kunye nezinye izifo ezizikhuselayo emzimbeni. Ikwaphandwe ukuba inako na ukunyanga i-COVID-19, nangona kufuneka uphando olongezelelekileyo ukuqinisekisa ukusebenza kwayo.

I-Artemether ngokubanzi ikhuselekile kwaye iyanyamezela xa isetyenziswa njengoko kuyalelwe. Nangona kunjalo, njengazo zonke iziyobisi, inokubangela iziphumo ebezingalindelekanga. Iziphumo ebezingalindelekanga eziqhelekileyo ze-artemether ziquka isicaphucaphu, ukuhlanza, isiyezi, kunye nentloko ebuhlungu. Kwiimeko ezingaqhelekanga, inokubangela iziphumo ezimbi kakhulu, ezifana nokubetha kwentliziyo, ukuxhuzula, kunye nomonakalo wesibindi.

Ukuqukumbela, i-artemether liyeza elinamandla lokulwa nemalariya eliye laguqula unyango kunye nokuthintela imalariya. Ukufunyanwa kwayo kusindise ubomi obungenakubalwa kwaye kwafumana udumo kuluntu lwezenzululwazi. Ezinye iimpawu zayo zonyango ziyenza ibe ngumviwa othembisayo kunyango lwezinye izifo. Nangona inokubangela iziphumo ebezingalindelekanga, iingenelo zayo zingaphezulu kakhulu kuneengozi zayo xa isetyenziswa phantsi kweliso logqirha.
Iifom zedosi ezisetyenziswa kakhulu ziquka iipilisi, iikhaphu kunye neenaliti. Iintlobo zamayeza ngamayeza okulwa nemalariya, kwaye eyona nto iphambili yi-artemether. Uphawu olubangela iipilisi ze-artemether yayiziipilisi ezimhlophe. Uphawu lwekhaphu ye-artemether yikhaphu, umxholo wayo ingumgubo omhlophe; Uphawu lweyeza lokufakwa kwe-artemether alunambala ukuya koluphuzi olukhanyayo - njengolwelo.