I-Astaxanthin (i-3,3'-dihydroxy-beta, i-beta-carotene-4,4'-dione) yi-carotenoid, ehlelwa njenge-lutein, efumaneka kwiindidi ezininzi ze-microorganisms kunye nezilwanyana zaselwandle, kwaye ekuqaleni yayingahlukaniswa ne-lobster nguKuhn no-Sorensen. Yibala eli-orenji elinyibilikayo elibonakala li-orenji ukuya kutsho kobomvu nzulu ngombala kwaye ayinayo i-vitamin A esebenzayo emzimbeni womntu.
Imithombo yendalo ye-astaxanthin ibandakanya i-algae, igwele, i-salmon, i-trout, i-krill kunye ne-crayfish. I-astaxanthin yorhwebo ithathwa ikakhulu kwigwele le-Fife, i-algae ebomvu kunye ne-chemical synthesis. Omnye wemithombo engcono kakhulu ye-astaxanthin yendalo yi-chlorella ebomvu enemvula, enomxholo we-astaxanthin malunga ne-3.8% (ngobunzima obomileyo), kunye ne-salmon yasendle nayo iyimithombo emihle ye-astaxanthin. Imveliso ye-Synthetic isengowona mthombo uphambili we-astaxanthin ngenxa yeendleko eziphezulu zokulima okukhulu kweRhodococcus rainieri. Umsebenzi webhayoloji we-astaxanthin eveliswe ngokwenziwa yi-50% kuphela ye-astaxanthin yendalo.
I-Astaxanthin ikhona njenge-stereoisomers, ii-isomers zejometri, iifom zasimahla kunye ne-esterified, ezine-stereoisomers (3S,3'S) kunye ne-(3R,3'R) zizezona zininzi kwindalo. I-Rhodococcus rainieri ivelisa i-(3S,3'S)-isomer kunye ne-Fife yeast ivelisa i-(3R,3'R) -isomer.
I-Astaxanthin, ubushushu bomzuzu
I-Astaxanthin iyisithako seenkwenkwezi kukutya okusebenzayo eJapan.Izibalo zeFTA kwizibhengezo zokutya ezisebenzayo eJapan kwi-2022 zifumene ukuba i-astaxanthin ibekwe kwindawo ye-7 phakathi kwezithako eziphezulu ze-10 ngokuphindaphindiweyo kokusetyenziswa, kwaye yayisetyenziswa kakhulu kwiinkalo zempilo ze-skincare, ukunakekelwa kwamehlo, ukukhululeka kokukhathala, kunye nokuphuculwa komsebenzi wokuqonda.
Kwi-2022 kunye ne-2023 ye-Asian Nutritional Ingredients Awards,Impilo entle nje Isithako se-astaxanthin sendalo saqatshelwa njengesona sithako silungileyo sonyaka iminyaka emibini elandelelanayo, eyona nto ingcono kakhulu kwi-cognitive track track kwi-2022, kunye neyona nto ingcono kwingoma yobuhle bomlomo ngo-2023.
Kwiminyaka yakutshanje, uphando lwezifundo kwi-astaxanthin nalo luqalisile ukutshisa. Ngokwedatha yePubMed, kwangowe-1948, bekukho izifundo kwi-astaxanthin, kodwa ingqwalasela ibiphantsi, ukuqala ngo-2011, i-academia yaqala ukugxila kwi-astaxanthin, kunye nopapasho olungaphezulu kwe-100 ngonyaka, nangaphezulu kwama-200 ngo-2017, ngaphezulu kwama-300 ngo-2020, kwaye ngaphezulu kwe-2020.
Umthombo womfanekiso:PubMed
Ngokwemarike, ngokwembono yemarike yekamva, ubungakanani bemakethi ye-astaxanthin yehlabathi buqikelelwa ukuba buzizigidi ezingama-273.2 zeedola ngo-2024 kwaye kuqikelelwa ukuba bufikelele kwi-USD 665.0 yezigidi ngo-2034, kwi-CAGR ye-9.3% ngexesha loqikelelo (2024-2034).
Umthamo ophezulu we-antioxidant
Ulwakhiwo olukhethekileyo lwe-Astaxanthin lunika amandla aphezulu e-antioxidant. I-Astaxanthin iqulethe i-conjugated double bonds, i-hydroxyl kunye namaqela e-ketone, kwaye zombini i-lipophilic kunye ne-hydrophilic. Ibhondi edityanisiweyo ephindwe kabini kumbindi wekhompawundi ibonelela ngee-elektroni kwaye isabela ngeeradicals zasimahla ukuziguqulela kwiimveliso ezizinzileyo kwaye ziphelise ukusabela kwetsheyini yeradical yasimahla kwizinto ezahlukeneyo. Umsebenzi wayo webhayoloji uphezulu kunezinye i-antioxidants ngenxa yokukwazi ukudibanisa kwiinwebu zeseli ukusuka ngaphakathi ngaphandle.
Indawo ye-astaxanthin kunye nezinye i-antioxidants kwiimbrane zeseli
I-Astaxanthin yenza umsebenzi obalulekileyo wokulwa ne-antioxidant kungekuphela nje ngokucoca ngokuthe ngqo ii-radicals zasimahla, kodwa nangokusebenza kwenkqubo yokukhusela i-antioxidant yeselula ngokulawula i-nuclear factor erythroid 2-related factor (Nrf2) indlela. I-Astaxanthin ithintela ukwenziwa kwe-ros kwaye ilawula ukubonakaliswa kwee-enzymes ze-oxidatives, njengeyona nto ilawulwa yi-oxy.ho-1 ilawulwa yiNSF2, elawula i-Antioxid Sen-Derical Demerism Enzymes.
Uluhlu olupheleleyo lweenzuzo ze-astaxanthin kunye nokusetyenziswa
1) Ukuphuculwa komsebenzi wokuqonda
Uphononongo oluninzi luqinisekisile ukuba i-astaxanthin inokulibazisa okanye iphucule ukusilela kwengqondo okuhambelana nokuguga okuqhelekileyo okanye kunciphise i-pathophysiology yezifo ezahlukeneyo ze-neurodeergenerative. I-Astaxanthin inokuwela umqobo wegazi-ingqondo, kwaye izifundo zibonise ukuba i-astaxanthin yokutya iqokelelana kwi-hippocampus kunye ne-cerebral cortex yobuchopho begundane emva kokuthatha okukodwa kunye nokuphindaphindiweyo, okunokuthi kuchaphazele ukugcinwa kunye nokuphuculwa komsebenzi wokuqonda. I-Astaxanthin ikhuthaza ukuvuselelwa kweeseli ze-nerve kunye nokwandisa i-gene expression of glial fibrillary acidic protein (GFAP), iprotheni ehambelana ne-microtubule 2 (MAP-2), i-brain-derived neurotrophic factor (BDNF), kunye neprotheyini ehambelana nokukhula kwe-43 (GAP-43), iiprotheyini ezichaphazelekayo ekubuyiseleni ingqondo.
I-Justgood Health Astaxanthin Capsules, kunye neCytisine kunye ne-Astaxanthin evela kwi-Red Algae Rainforest, i-synergize ukuphucula umsebenzi wokuqonda kwengqondo.
2) Ukukhuselwa kwamehlo
I-Astaxanthin inomsebenzi we-antioxidant owenza ukuba i-oksijini isebenze ii-radical molecules kwaye inikeze ukhuseleko lwamehlo. I-Astaxanthin isebenza ngokubambisana nezinye ii-carotenoids ezixhasa impilo yamehlo, ngakumbi i-lutein kunye ne-zeaxanthin. Ukongeza, i-astaxanthin yonyusa izinga lokuhamba kwegazi kwiliso, ivumela igazi ukuba liphinde likhuphe i-retina kunye nezicubu zamehlo. Uphononongo lubonise ukuba i-astaxanthin, idityaniswe nezinye ii-carotenoids, ikhusela amehlo emonakalweni kwi-spectrum yelanga. Ukongeza, i-astaxanthin inceda ukukhulula ukungonwabi kwamehlo kunye nokudinwa okubonakalayo.
I-Justgood Health Blue Light Protection Softgels, izithako eziphambili: i-lutein, i-zeaxanthin, i-astaxanthin.
3) Ukunakekelwa kwesikhumba
Uxinzelelo lwe-oxidative luyisiqalo esibalulekileyo sokuguga kwesikhumba somntu kunye nomonakalo wesikhumba. Indlela yokuguga yangaphakathi (yexesha elide) kunye ne-extrinsic (ukukhanya) kukuveliswa kwe-ROS, ngaphakathi nge-oxidative metabolism, kunye nangaphandle ngokuvezwa kwimitha ye-ultraviolet (UV) yelanga. Iziganeko ze-Oxidative ekugugeni kwesikhumba ziquka umonakalo we-DNA, iimpendulo ezivuthayo, ukunciphisa i-antioxidants, kunye nokuveliswa kwe-matrix metalloproteinases (MMPs) ehlisa i-collagen kunye ne-elastin kwidermis.
I-Astaxanthin inokuthintela ngokufanelekileyo umonakalo owenziwe nge-radical-induced oxidative kunye nokungeniswa kwe-MMP-1 eluswini emva kokuvezwa kwe-UV. Uphononongo lubonise ukuba i-astaxanthin evela kwi-Erythrocystis rainbowensis inokunyusa umxholo we-collagen ngokuthintela ukubonakaliswa kwe-MMP-1 kunye ne-MMP-3 kwi-fibroblasts yedermal yabantu. Ukongeza, i-astaxanthin inciphise umonakalo we-UV-induced DNA kunye nokwandisa ukulungiswa kwe-DNA kwiiseli ezivezwe imitha ye-UV.
I-Justgood Health okwangoku iqhuba izifundo ezininzi, kubandakanywa iimpuku ezingenaboya kunye nezilingo zabantu, zonke eziye zabonisa ukuba i-astaxanthin iyanciphisa umonakalo we-UV kumagumbi anzulu olusu, obangela ukubonakala kweempawu zokuguga kwesikhumba, njengokoma, ukucwina kwesikhumba kunye nemibimbi.
4) Isondlo sezemidlalo
I-Astaxanthin inokukhawulezisa ukulungiswa kwasemva kokuzivocavoca. Xa abantu bezilolonga okanye basebenze, umzimba uvelisa inani elikhulu le-ROS, leyo, ukuba ingasuswanga ngexesha, inokonakalisa imisipha kwaye ithintele ukubuyiswa komzimba, ngelixa i-astaxanthin inamandla e-antioxidant function inokususa i-ROS ngexesha kwaye ilungise izihlunu ezonakalisiweyo ngokukhawuleza.
I-Justgood Health yazisa i-Astaxanthin Complex yayo entsha, i-multi-blend ye-magnesium glycerophosphate, i-vitamin B6 (pyridoxine), kunye ne-astaxanthin eyanciphisa intlungu ye-muscle kunye nokukhathala emva kokuzivocavoca. Ifomula igxile kwi-Justgood Health's Whole Algae Complex, ehambisa i-astaxanthin yendalo engakhuseli kuphela izihlunu kumonakalo owenziwe nge-oxidative, kodwa iphucula ukusebenza kwezihlunu kunye nokuphucula ukusebenza kwezemidlalo.
5) Impilo ye-Cardiovascular
Uxinzelelo lwe-oxidative kunye nokuvuvukala luphawu lwe-pathophysiology ye-atherosclerotic cardiovascular disease. Umsebenzi obalaseleyo we-antioxidant we-astaxanthin unokuthintela kunye nokuphucula i-atherosclerosis.
I-Justgood Health Triple Strength Natural Astaxanthin Softgels inceda ukugcina impilo ye-cardiovascular ngokusebenzisa i-astaxanthin yendalo efunyenwe kwi-rainbow algae ebomvu, izithako eziphambili ezibandakanya i-astaxanthin, i-oyile ye-coconut ye-organic virgin kunye ne-tocopherols yendalo.
6) Ulawulo lwamajoni omzimba
Iiseli zenkqubo yamajoni omzimba zinovelwano kakhulu kumonakalo omkhulu wasimahla. I-Astaxanthin ikhusela amajoni omzimba ngokuthintela umonakalo omkhulu wasimahla. Uphononongo lufumene ukuba i-astaxanthin kwiiseli zomntu ukuvelisa i-immunoglobulins, emzimbeni womntu i-astaxanthin supplementation kwiiveki ze-8, amanqanaba e-astaxanthin egazini anda, iiseli ze-T kunye neeseli ze-B zanda, umonakalo we-DNA uyancipha, iprotheni ye-C-reactive iyancipha kakhulu.
I-astaxanthin softgels, i-astaxanthin eluhlaza, isebenzisa ukukhanya kwelanga kwendalo, amanzi ahluzwe yilava kunye namandla elanga ukuvelisa i-astaxanthin ecocekileyo nesempilweni, enokunceda ukomeleza ukungatheleleki, ukukhusela umbono kunye nempilo edibeneyo.
7) Nciphisa Ukukhathala
I-4-iveki ye-4 i-randomized, i-double-blind, i-placebo-controlled, i-placebo-controlled controlled, i-astaxanthin ikhuthaza ukubuyiswa kwi-terminal display display (VDT) -ibangela ukukhathala kwengqondo, ukunciphisa i-plasma phosphatidylcholine hydroperoxide (PCOOH) ephakamileyo ngexesha lomsebenzi wengqondo kunye nomzimba. Isizathu sinokuba ngumsebenzi we-antioxidant kunye ne-anti-inflammatory mechanism ye-astaxanthin.
8) Ukukhuselwa kwesibindi
I-Astaxanthin ineempembelelo zothintelo kunye nokuphucula iingxaki zempilo ezifana ne-fibrosis yesibindi, isibindi se-ischemia-reperfusion ukulimala, kunye ne-NAFLD. I-Astaxanthin inokulawula iindlela ezahlukeneyo zokubonisa iimpawu, ezifana nokunciphisa i-JNK kunye ne-ERK-1 umsebenzi wokuphucula ukuxhatshazwa kwe-insulin ye-hepatic, inqanda ukubonakaliswa kwe-PPAR-γ ukunciphisa i-fat hepatic synthesis, kunye ne-down-regulating TGF-β1 / Smad3 inkcazo yokuvimbela ukusebenza kwe-HSC kunye ne-fibrosis yesibindi.
Ubume bemimiselo kwilizwe ngalinye
ETshayina,i-astaxanthin ukusuka kumthombo we-rainbow algae ebomvu ingasetyenziswa njengesithako esitsha sokutya ekutyeni ngokubanzi (ngaphandle kokutya komntwana), ukongeza, i-United States, iCanada kunye neJapan nayo ivumela i-astaxanthin ukuba isetyenziswe ekutyeni .
Ixesha lokuposa: Dec-05-2024