I-Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) yi-carotenoid, ehlelwe njenge-lutein, efumaneka kwiintlobo ngeentlobo zeentsholongwane kunye nezilwanyana zaselwandle, kwaye ekuqaleni yahlulwa kwiilobster nguKuhn noSorensen. Yipigment enyibilikayo emafutheni ebonakala ngathi yiorenji ukuya kubomvu kwaye ayinayo i-vitamin A pro-activity emzimbeni womntu.
Imithombo yendalo ye-astaxanthin ibandakanya i-algae, i-yeast, i-salmon, i-trout, i-krill kunye ne-crayfish. I-astaxanthin yorhwebo ifumaneka kakhulu kwi-Fife yeast, i-red algae kunye nokuhlanganiswa kweekhemikhali. Enye yezona mithombo zibalaseleyo ze-astaxanthin yendalo yi-chlorella ebomvu eyondliwe yimvula, enomxholo we-astaxanthin omalunga ne-3.8% (ngokobunzima obomileyo), kwaye i-salmon yasendle nayo yimithombo elungileyo ye-astaxanthin. Imveliso yokwenziwa isengumthombo ophambili we-astaxanthin ngenxa yeendleko eziphezulu zokulima i-Rhodococcus rainieri ngobuninzi. Umsebenzi webhayoloji we-astaxanthin eveliswe ngokwenziwa yi-50% kuphela yaleyo ye-astaxanthin yendalo.
I-Astaxanthin ikhona njengee-stereoisomers, ii-geometric isomers, iifom ezikhululekileyo neziqinisekisiweyo, kunye nee-stereoisomers (3S,3'S) kunye ne-(3R,3'R) zezona zininzi kakhulu kwindalo. I-Rhodococcus rainieri ivelisa i-(3S,3'S)-isomer kwaye i-Fife yeast ivelisa i-(3R,3'R)-isomer.
I-Astaxanthin, ubushushu balo mzuzu
I-Astaxanthin sisithako esibalaseleyo ekutyeni okusebenzayo eJapan. Izibalo ze-FTA malunga nezibhengezo zokutya okusebenzayo eJapan ngo-2022 zifumanise ukuba i-astaxanthin yayibekwe kwindawo yesi-7 phakathi kwezithako ezili-10 eziphezulu ngokwexesha lokusetyenziswa, kwaye yayisetyenziswa kakhulu kwicandelo lezempilo lokhathalelo lolusu, ukhathalelo lwamehlo, ukukhululeka ekudinweni, kunye nokuphucula ukusebenza kwengqondo.
KwiMbasa yeZithako zeSondlo zaseAsia zowama-2022 nowama-2023,Impilo yeJustgood Isithako sendalo se-astaxanthin saqatshelwa njengesithako esibalaseleyo sonyaka kangangeminyaka emibini ilandelelana, isithako esibalaseleyo kwithrekhi yokusebenza kwengqondo ngo-2022, kunye nesithako esibalaseleyo kwithrekhi yobuhle bomlomo ngo-2023. Ukongeza, esi sithako safakwa kuluhlu olufutshane kwi-Asian Nutritional Ingredients Awards - Healthy Aging track ngo-2024.
Kwiminyaka yakutshanje, uphando lwezemfundo malunga ne-astaxanthin nalo luqale ukufudumala. Ngokwedatha yePubMed, kwasekuqaleni kowe-1948, bekukho izifundo malunga ne-astaxanthin, kodwa ingqwalasela ibiphantsi, ukususela ngo-2011, amaziko emfundo aqala ukugxila kwi-astaxanthin, ngeempapasho ezingaphezu kwe-100 ngonyaka, nangaphezulu kwama-200 ngo-2017, ngaphezulu kwama-300 ngo-2020, nangaphezulu kwama-400 ngo-2021.
Umthombo womfanekiso: I-PubMed
Ngokuphathelele imakethi, ngokwe-Future market insights, ubungakanani bemakethi ye-astaxanthin yehlabathi buqikelelwa ukuba yi-USD 273.2 yezigidi ngo-2024 kwaye kulindeleke ukuba ifikelele kwi-USD 665.0 yezigidi ngo-2034, kwi-CAGR ye-9.3% ngexesha lexesha eliqikelelweyo (2024-2034).
Umthamo ophezulu we-antioxidant
Isakhiwo esikhethekileyo se-Astaxanthin sisinika amandla amangalisayo okulwa ne-antioxidant. I-Astaxanthin inee-conjugated double bonds, amaqela e-hydroxyl kunye ne-ketone, kwaye i-lipophilic kunye ne-hydrophilic. I-conjugated double bond esembindini we-compound inika ii-electron kwaye isabela kunye nee-free radicals ukuze ziguqulwe zibe ziimveliso ezizinzileyo kwaye ziphelise ii-free radical chain reactions kwizinto ezahlukeneyo eziphilayo. Umsebenzi wayo webhayoloji ungcono kunowezinye ii-antioxidants ngenxa yokukwazi kwayo ukunxibelelana nee-membrane zeseli ukusuka ngaphakathi ukuya ngaphandle.
Indawo ye-astaxanthin kunye nezinye ii-antioxidants kwi-membranes yeseli
I-Astaxanthin inomsebenzi obalulekileyo we-antioxidant kungekuphela nje ngokucoca ngokuthe ngqo ii-free radicals, kodwa nangokuvuselela inkqubo yokuzikhusela ye-antioxidant yeselula ngokulawula indlela ye-nuclear factor erythroid 2-related factor (Nrf2). I-Astaxanthin ithintela ukwakheka kwe-ROS kwaye ilawula ukubonakaliswa kwee-enzymes eziphendula uxinzelelo lwe-oxidative, ezifana ne-heme oxygenase-1 (HO-1), oluphawu loxinzelelo lwe-oxidative. I-HO-1 ilawulwa ziintlobo ngeentlobo zezinto ezibangela uxinezeleko, kubandakanya i-Nrf2, ebopha kwizinto eziphendula uxinezeleko kwindawo yokukhuthaza ii-enzymes ze-metabolism ye-detoxification.
Uluhlu olupheleleyo lweenzuzo ze-astaxanthin kunye nokusetyenziswa kwazo
1) Ukuphuculwa komsebenzi wokuqonda
Izifundo ezininzi ziqinisekisile ukuba i-astaxanthin inokulibazisa okanye iphucule iingxaki zengqondo ezinxulumene nokwaluphala okuqhelekileyo okanye inciphise i-pathophysiology yezifo ezahlukeneyo ze-neurodegenerative. I-Astaxanthin inokunqumla umqobo wegazi-ubuchopho, kwaye izifundo zibonise ukuba i-astaxanthin yokutya iqokelelana kwi-hippocampus kunye ne-cerebral cortex yengqondo yegundane emva kokutya kanye nokuphindaphindiweyo, oku kunokuchaphazela ukugcinwa kunye nokuphuculwa komsebenzi wokuqonda. I-Astaxanthin ikhuthaza ukuvuselelwa kweeseli zemithambo-luvo kwaye inyusa ukubonakaliswa kwezakhi zofuzo ze-glial fibrillary acidic protein (GFAP), i-microtubule-associated protein 2 (MAP-2), i-brain-derived neurotrophic factor (BDNF), kunye ne-growth-associated protein 43 (GAP-43), iiproteni ezibandakanyeka ekubuyiselweni kwengqondo.
IiCapsules zeJustgood Health Astaxanthin, kunye neCytisine kunye neAstaxanthin ezivela kwiRed Algae Rainforest, ziyasebenzisana ukuphucula ukusebenza kwengqondo.
2) Ukhuseleko lwamehlo
I-Astaxanthin inomsebenzi we-antioxidant othintela iimolekyuli ze-oxygen free radical kwaye ikhusela amehlo. I-Astaxanthin isebenza ngokubambisana nezinye ii-carotenoids ezixhasa impilo yamehlo, ngakumbi i-lutein kunye ne-zeaxanthin. Ukongeza, i-astaxanthin yonyusa izinga lokuhamba kwegazi elisweni, ivumela igazi ukuba livuselele i-oxygen kwi-retina kunye nezicubu zamehlo. Izifundo zibonise ukuba i-astaxanthin, kunye nezinye ii-carotenoids, ikhusela amehlo ekonakaleni kwi-spectrum yelanga. Ukongeza, i-astaxanthin inceda ekunciphiseni ukungonwabi kwamehlo kunye nokudinwa kokubona.
Iisoftgels zeJustgood Health Blue Light Protection, Izithako eziphambili: i-lutein, i-zeaxanthin, i-astaxanthin.
3) Ukhathalelo lolusu
Uxinzelelo lwe-oxidative luyinto ebalulekileyo ebangela ukuguga kwesikhumba somntu kunye nomonakalo wesikhumba. Indlela yokuguga kwangaphakathi (kwexesha) kunye nokwangaphandle (ukukhanya) kukuveliswa kwe-ROS, ngaphakathi ngokusebenzisa i-oxidative metabolism, nangaphandle ngokuchatshazelwa yimitha yelanga ye-ultraviolet (UV). Iziganeko ze-oxidative ekwaluphaleni kwesikhumba ziquka umonakalo we-DNA, iimpendulo zokudumba, ukunciphisa ii-antioxidants, kunye nokuveliswa kwee-matrix metalloproteinases (MMPs) ezitshabalalisa i-collagen kunye ne-elastin kwi-dermis.
I-Astaxanthin inokuthintela ngempumelelo umonakalo we-oxidative obangelwa yi-free radical kunye nokufakwa kwe-MMP-1 eluswini emva kokuvezwa yi-UV. Izifundo zibonise ukuba i-astaxanthin evela kwi-Erythrocystis rainbowensis inokunyusa umxholo we-collagen ngokuthintela ukubonakaliswa kwe-MMP-1 kunye ne-MMP-3 kwi-fibroblasts yesikhumba somntu. Ukongeza, i-astaxanthin yanciphisa umonakalo we-DNA obangelwa yi-UV kwaye yandisa ukulungiswa kwe-DNA kwiiseli ezivezwe kwimitha ye-UV.
I-Justgood Health okwangoku iqhuba izifundo ezininzi, kuquka iimpuku ezingenaboya kunye novavanyo lwabantu, zonke ezibonise ukuba i-astaxanthin iyanciphisa umonakalo we-UV kwiindawo ezinzulu zolusu, nto leyo ebangela ukubonakala kweempawu zokwaluphala kolusu, njengokoma, ulusu olugobileyo kunye nemibimbi.
4) Isondlo sezemidlalo
I-Astaxanthin inokukhawulezisa ukulungiswa emva kokuzilolonga. Xa abantu bezilolonga okanye bezilolonga, umzimba uvelisa inani elikhulu le-ROS, ethi, ukuba ayisuswanga ngexesha, ingonakalisa izihlunu kwaye ichaphazele ukuchacha komzimba, ngelixa umsebenzi onamandla we-astaxanthin wokulwa ne-antioxidant unokususa i-ROS ngexesha kwaye ulungise izihlunu ezonakeleyo ngokukhawuleza.
I-Justgood Health yazisa i-Astaxanthin Complex yayo entsha, umxube omninzi we-magnesium glycerophosphate, i-vitamin B6 (pyridoxine), kunye ne-astaxanthin enciphisa iintlungu zemisipha kunye nokudinwa emva kokuzilolonga. Le fomula igxile kwi-Whole Algae Complex ye-Justgood Health, enika i-astaxanthin yendalo engakhuseli nje kuphela izihlunu kumonakalo we-oxidative, kodwa ikwaphucula ukusebenza kwezihlunu kwaye iphucule ukusebenza kwezemidlalo.
5) Impilo yeNtliziyo neMithambo
Uxinzelelo lwe-oxidative kunye nokudumba zimpawu ze-pathophysiology yesifo sentliziyo esine-atherosclerotic. Umsebenzi ogqwesileyo we-astaxanthin wokulwa ne-antioxidant unokuthintela kwaye uphucule i-atherosclerosis.
I-Justgood Health Triple Strength Natural Astaxanthin Softgels inceda ukugcina impilo yentliziyo ngokusebenzisa i-astaxanthin yendalo evela kwi-rainbow red algae, izithako eziphambili zayo ziquka i-astaxanthin, i-organic virgin coconut oil kunye ne-tocopherols yendalo.
6) Ulawulo loMzimba
Iiseli zenkqubo yomzimba yokuzikhusela zibuthathaka kakhulu kumonakalo we-free radicals. I-Astaxanthin ikhusela ukhuselo lwenkqubo yomzimba yokuzikhusela ngokuthintela umonakalo we-free radicals. Uphononongo lufumanise ukuba i-astaxanthin kwiiseli zabantu ukuvelisa ii-immunoglobulins, emzimbeni womntu ukongezwa kwe-astaxanthin iiveki ezi-8, amanqanaba e-astaxanthin egazini ayanda, iiseli ze-T kunye neeseli ze-B zanda, umonakalo we-DNA uyancipha, iprotheyini ye-C-reactive iyancipha kakhulu.
Ii-softgels ze-Astaxanthin, i-astaxanthin eluhlaza, zisebenzisa ukukhanya kwelanga kwendalo, amanzi ahluzwe yi-lava kunye namandla elanga ukuvelisa i-astaxanthin ecocekileyo nesempilweni, enokunceda ukuphucula amajoni omzimba, ukukhusela umbono kunye nempilo yamalungu.
7) Nciphisa Ukudinwa
Uphononongo lweeveki ezi-4 oluqhutywa ngokungacwangciswanga, olungaboni kabini, olulawulwa yi-placebo, noluqhutywa ngeendlela ezimbini lufumanise ukuba i-astaxanthin ikhuthaza ukuchacha kwi-visual display terminal (VDT)-induced mental fatigue, nto leyo enciphisa amanqanaba aphezulu e-plasma phosphatidylcholine hydroperoxide (PCOOH) ngexesha lomsebenzi wengqondo nowomzimba. Isizathu sisenokuba ngumsebenzi we-antioxidant kunye nendlela yokulwa nokuvuvukala ye-astaxanthin.
8) Ukukhuselwa kwesibindi
I-Astaxanthin ineziphumo zokuthintela nokuphucula iingxaki zempilo ezifana ne-liver fibrosis, ukwenzakala kwe-ischemia-reperfusion yesibindi, kunye ne-NAFLD. I-Astaxanthin inokulawula iindlela ezahlukeneyo zokubonisa, njengokunciphisa umsebenzi we-JNK kunye ne-ERK-1 ukuphucula ukumelana ne-insulin yesibindi, ukuthintela ukubonakaliswa kwe-PPAR-γ ukunciphisa ukwenziwa kwamafutha esibindini, kunye nokunciphisa ukubonakaliswa kwe-TGF-β1/Smad3 ukuthintela ukusebenza kwe-HSCs kunye ne-liver fibrosis.
Imeko yemigaqo kwilizwe ngalinye
ETshayina,i-astaxanthin Ukusuka kumthombo we-rainbow red algae ingasetyenziswa njengesithako esitsha sokutya ekutyeni ngokubanzi (ngaphandle kokutya komntwana), ukongeza, i-United States, iKhanada kunye neJapan nazo zivumela ukusetyenziswa kwe-astaxanthin ekutyeni.
Ixesha lokuthumela: Disemba-05-2024