Kwiminyaka yakutshanje, ingxaki yokutyeba kwihlabathi liphela iye yaba mandundu ngakumbi. Ngokutsho kwe-"Global Obesity Atlas 2025" ekhutshwe yiWorld Obesity Federation, inani lilonke labantu abadala abatyebe kakhulu kwihlabathi liphela kulindeleke ukuba linyuke ukusuka kwizigidi ezingama-524 ngo-2010 ukuya kwi-1.13 yeebhiliyoni ngo-2030, ukwanda okungaphezulu kwe-115%. Ngenxa yesi sizathu, inani elikhulayo labathengi lifuna izithako zendalo ezinokunceda ekuthinteleni ukutyeba kakhulu. NgoJuni kulo nyaka, uphando olupapashwe kwiphephancwadi elithi "npj science of food" lubonise ukuba i-curcumin inciphise ukuqokelelwa kwamafutha e-visceral kwiimpuku ze-MASH ngokuthintela ukukhululwa kwe-gastric inhibitory polypeptides (GIP) ebangelwa kukulimala kwamathumbu okungena-oxygen. Oku kufunyanisiweyo akuboneleli nje kuphela ngeengcinga ezintsha zokulwa nokutyeba kodwa kwandisa nemarike yesicelo se-curcumin.
I-curcumin iyithintela njani ingqokelela yamafutha e-visceral? Ingqokelela yamafutha e-visceral ibhekisa ekuqokeleleni kwamafutha okungaqhelekanga okanye okugqithisileyo. Ukutya okune-carbohydrate ephezulu, ukutya okunamafutha amaninzi kunye nokungazilolongi konke oku kunokubangela ukungalingani kwamandla, ngaloo ndlela kubangele amafutha e-visceral amaninzi. Indlela yokugaya ukutya yindawo ephambili yokufunxa amafutha. Ingqokelela yamafutha e-visceral luphawu olubalulekileyo lwe-steatohepatitis (MASH) enxulumene nokungasebenzi kakuhle kwe-metabolic. Ngokophando, zombini i-curcumin kunye ne-antibiotics zinokunciphisa ubunzima bomzimba weempuku ze-MASH, kwaye i-curcumin kunye ne-antibiotics zinefuthe elihambelanayo.
Uphando lwendlela yokusebenza lufumanise ukuba i-curcumin inciphisa ubunzima bamafutha e-visceral, ingakumbi kwizicubu ze-perirenal. I-Curcumin ithintela ukwanda kobunzima ngokuthintela ukukhululwa kwe-GIP kunye nokunciphisa isalathisi sezicubu ze-adipose ezijikeleze izintso. Ukunciphisa ukukhululwa kwe-GIP yamathumbu okubangelwa yi-curcumin kuthintela ukusebenza kwee-receptors ze-GIP, ngaloo ndlela kunciphisa i-adipogenesis kunye nokuvuvukala kwizicubu ze-perirenal adipose. Ukongeza, i-curcumin inokunciphisa i-hypoxia yamathumbu amancinci ngokukhusela i-epithelium yamathumbu kunye nomqobo wemithambo yegazi, ngaloo ndlela kunciphisa ukukhululwa kwe-GIP. Ukuqukumbela, isiphumo se-pharmacological se-curcumin kumafutha e-visceral sinciphisa ukukhululwa kwe-GIP ngokuthintela i-hypoxia ebangelwa kukuphazamiseka komqobo wamathumbu.
I-Curcumin, "ingcali yokulwa nokuvuvukala", ikakhulu ivela kwiingcambu kunye neerhizomes zeCurcuma (Curcuma longa L.). Yikhompawundi ye-polyphenolic ephantsi kwaye idla ngokusetyenziswa njengesinongo kwiintlobo ngeentlobo zokutya. Ngo-1815, uVegel nabanye baqala ukubika ngokuhlukaniswa "kwento etyheli eorenji" kwi-rhizome ye-turmeric baza bayibiza ngokuba yi-curcumin. Kwakungekho kude kube ngu-1910 apho uKazimierz kunye nabanye oososayensi bagqiba ukuba isakhiwo sayo seekhemikhali yi-diferulic acylmethane. Ubungqina obukhoyo bubonisa ukuba i-curcumin inesiphumo esibalulekileyo sokulwa nokuvuvukala. Ingasebenzisa isiphumo sayo sokulwa nokuvuvukala ngokuthintela indlela ye-Toll-like receptor 4 (TLR4) kunye nendlela yayo yokubonisa ye-nuclear factor kB (NF-kB), kunye nokunciphisa imveliso yezinto ezibangela ukuvuvukala ezifana ne-interleukin-1 β(IL-1β) kunye ne-tumor necrosis factor -α(TNF-α). Okwangoku, iipropati zayo zokulwa nokuvuvukala zithathwa njengesiseko semisebenzi eyahlukeneyo yebhayoloji, kwaye inani elikhulu lezifundo zangaphambi konyango okanye zeklinikhi zihlolisise ukusebenza kwayo kwizifo zokuvuvukala. Phakathi kwazo, isifo samathumbu esivuthayo, isifo samathambo, i-psoriasis, uxinzelelo, i-atherosclerosis kunye ne-COVID-19 zezona ndawo ziphambili zophando.
Ngokukhula kwemarike yanamhlanje, kunzima ukufikelela kwidosi esebenzayo ngokutya kuphela kwaye kufuneka ithathwe ngendlela yezongezo. Ke ngoko, ikhule kakhulu kwicandelo lokutya okunempilo kunye nezongezo zokutya.
I-Justgood Health ikwaphuhlise iintlobo ngeentlobo zezongezo ze-curcumin gummy kunye nee-capsules ze-curcumin. Abasasazi abaninzi baye bazenzela ngokwezifiso idosi okanye imo yophawu lwabo.
Uphando olongezelelekileyo malunga neenzuzo ze-curcumin lufumanise ukuba i-curcumin ayincedi nje kuphela ukumelana nokutyeba kakhulu kodwa ineziphumo ezininzi ezifana nokulwa ne-oxidation, ukukhuselwa yi-neuro, ukukhululeka kwintlungu yamathambo kunye nokuxhasa impilo yentliziyo. I-Antioxidant: Uphando lufumanise ukuba i-curcumin inokususa ngokuthe ngqo ii-free radicals kwaye iphucule umsebenzi we-mitochondrial ngokusebenzisa iindlela ezifana nokuthulisa iproteni elawulayo i-3 (SIRT3), ngaloo ndlela inciphisa imveliso ye-oxygen species (ROS) egqithisileyo evela kumthombo kwaye inciphise ngempumelelo umonakalo we-oxidative weseli. Ukukhuselwa yi-Neuro: Ubungqina bophando obukhoyo bubonisa ukuba ukudumba kunxulumene kakhulu nokudakumba. I-Curcumin inokuphucula iimpawu zokudakumba kunye nokuxhalaba kwezigulane ezinexinzelelo. I-Curcumin inokunceda ukumelana nomonakalo we-neuronal obangelwa yi-interleukin-1 β (IL-1β) kunye nezinye izinto, kwaye inciphise ukuziphatha okufana nokudakumba okubangelwa luxinzelelo olungapheliyo. Ke ngoko, inokudlala indima entle ekuxhaseni impilo yengqondo kunye nokulawulwa kweemvakalelo. Ukuphelisa iintlungu ze-musculoskeletal: Izifundo zibonise ukuba i-curcumin inokuphucula iimpawu zeklinikhi zezilwanyana zemodeli ye-arthritis kwaye ikhusele izicubu zamalungu kunye nemisipha ngokunciphisa ukudumba. I-Curcumin inokuphelisa iintlungu zemisipha kuba inokuthintela kakhulu ukukhululwa kwezinto ezibangela ukudumba ezifana ne-tumor necrosis factor -α(TNF-α) kunye ne-interleukin-1 β(IL-1β), inciphise iimpendulo zokudumba zasekuhlaleni, ngaloo ndlela inciphise iimpawu zokudumba kwamalungu kunye nentlungu. Ukuxhasa impilo yentliziyo: Ngokwenkqubo yentliziyo, i-curcumin inokusebenza ngokulawula ii-lipids zegazi, inciphise i-cholesterol iyonke kwi-serum, i-triglycerides kunye namanqanaba e-cholesterol e-lipoprotein ephantsi, ngelixa inyusa amanqanaba e-cholesterol e-lipoprotein ephezulu. Ukongeza, i-curcumin inokuthintela ukwanda kweeseli zemisipha ezithambileyo zemithambo yegazi kunye neempendulo zokudumba, oku luncedo ekuthinteleni ukwenzeka kunye nophuhliso lwezifo zentliziyo ezifana ne-atherosclerosis.
Ixesha leposi: Jan-08-2026