Njengabantu abadala, ukwehla komsebenzi wobuchopho kuyabonakala ngakumbi. Phakathi kwabantu abaneminyaka engama-20 ukuya kwengama-489, uninzi luqala ukuqaphela ukwehla komsebenzi wengqondo xa befumana ukulahleka kwememori okanye ukulibala. Kwabo baneminyaka engama-50-5-59, ukufezekiswa kokuqonda kwengqondo kuhlala kuyeza xa beqala ukufumana ihla ngememori ebonakalayo.
Xa ujonge iindlela zokuphucula ukusebenza kwengqondo, amaqela ahlukeneyo yobudala agxile kwimiba eyahlukeneyo. Abantu abaneminyaka engama-20 ukuya kwengama-29 hlala begxila ekuphuculeni ukulala ukonyusa intsebenzo yengqondo (44.7%), ngelixa abantu abangama-30 ukuya kwengama-47.5%). Kwabo baneminyaka engama-40 ukuya kweli-25-59, ukuphucula ingqalelo kuthathwa njengeyona nto ithatyathwa ngumsebenzi wobuchopho (iminyaka engama-40 ukuya kwengama-409: 44%, iminyaka engama-43,4,4%).
Izithako ezithandwayo kwimakethi ye-Jabho yeMpilo
Ngokuhambelana nemeko yehlabathi yokuphila impilo esempilweni, imarike yokutya esebenzayo yaseJapan igxininisa ikakhulu isombululo kwimicimbi ethile yezempilo, ngengqondo yengqondo ibaluleke kakhulu. NgoDisemba 11, 2024, iJapan yayibhalisile ukutya okungu-1,012 Phakathi kwezi, uGaba wayesesona sithako sisetyenziswa rhoqo, silandelwelutein/Zeaxanthin, I-Ginkgo Gafting (i-flavonoids, ii-pronoids),Dha, I-Bifidobacterium McC1274, iPorulaca Oleracea Sandins, PaclimaXEL, IMIDEDAZEOLINE POPTIDES,Pqq, kwaye i-ergooneine.
1. Gaba
I-Gaba (i-γ-aminobyric acid) yi-Amino e-Amino-Amino e-Amino e-Amino e-Ino-I-Amino-Amino efunyenweyo ifunyenwe ngumphathi kunye noogxa bakhe kwizicubu ze-potato tud ngo-1945. Ngo-1950, i-roberts et al. I-Gaba e-Gaba e-Mammalian Foods, eyenziwe ngentloksisi engaphindiweyo ye-α ye-Glutamate okanye i-SALTS, inyathelwe yi-glutamate depcysbose.
I-Gaba yi-neurotranstater ebaluleke kakhulu efunyenwe kakhulu kwinkqubo ye-mammalian nevous. Umsebenzi wayo ophambili kukunciphisa ubugqwetha be-neuronal ngokuthintela ukuhanjiswa kweempawu zendalo. Kwingqondo, ibhalansi phakathi kwe-neurotrolorn and geba kunye ne-neurotroume ye-neurotranstory ye-Glutamate iyimfuneko ekugcineni uzinzo lweseli yeseli kunye nomsebenzi oqhelekileyo weseli.
Izifundo zibonisa ukuba i-Gaba ingathintela utshintsho lwe-neurodegenege kunye nokuphucula inkumbulo kunye nemisebenzi yokuqonda. Izifundo zezilwanyana zibonisa ukuba i-Gaba iphucula inkumbulo yexesha elide kwiimpuku ezinomhla wengqondo kunye nokukhuthaza ukwenziwa kweeseli ze-neuroendocrine PC-12. Kuvavanyo lweklinikhi, uGaba ubonisiwe ukwandisa i-serum ye-neurotrophic ye-neurotrophic factor (BDNF) kwaye unciphise umngcipheko wesifo sengqondo esixhalabisayo kunye nesifo se-Alzheimer kubafazi abakwi-Alzheimer kubafazi abakwi-Alzheimer kubafazi abakwi-Alzheimer.
Ukongeza, iGaba ineziphumo ezintle kwimozulu, uxinzelelo, ukudinwa, kunye nokulala. Uphando lubonisa ukuba umxube we-Gaba kunye no-L-vanine banokunciphisa ixesha lokulala, benyusa ubude bexesha lokulala, kwaye bachase intetho yeGaba kunye ne-glutamate gluun1 receptor.
I-2. I-LTEIN / Zeaxanthin
LuteinNgaba i-therotenoid ye-oxygenid edityaniswe ngentsalela yesibhozo i-Isoprene i-Isoene iqulathe iibhondi ezisithoba eziphindwe kabini, ezithatyathwayo kunye nokukhupha ukukhanya kumaza athile amaza.Zeaxanthinyi-isomer ye-LUTEIN, eyahlukileyo kwisikhundla seqhina eliphindwe kabini kwindandatho.
I-lutein kunye ne-zeaxanthinziimpawu eziphambili kwi-retina. I-LTein ifumaneka ikakhulu kwi-terinaral retina, ngelixa i-zeaxanthin igxile kwi-Macular ephakathi. Iziphumo zokhuselo zeI-lutein kunye ne-zeaxanthinKuba amehlo aquka ukuphucula umbono, ukuthintela ukwahlula i-sucture (AMD), iikati, i-glaucoma, kwaye uthintele kwakhona kwintsana engaphambi kwexesha.
Ngo-2017, abaphandi abavela kwiDyunivesithi yaseGeorgia bafumanisa ukubaI-lutein kunye ne-zeaxanthinIphembelele kakuhle impilo yengqondo kubantu abadala abadala. Isifundo sibonise ukuba abathathi-nxaxheba abanamanqanaba aphezuluI-lutein kunye ne-zeaxanthinUkuboniswa kwengqondo esezantsi yengqondo xa usenza imisebenzi-bhatalela eyokukhumbula, ephakamisa ukusebenza kakuhle.
Ukongeza, isifundo sinike ingxelo yokuba i-Lutemax 2020, i-LTIIN eyongezelelekileyo kwi-omeo, yandise kakhulu inqanaba le-BDNF (i-Neurotrophic evaliweyo), iproteyini ebalulekileyo ebandakanyekayo kwi-neurons, kunye nememori yokufunda, kunye nokusebenza kwengqondo.
(Iifomula zesakhiwo se-Lutein kunye ne-Zeaxanthin)
I-3. Igqabi le-Ginkgo Exhume (i-flavonoids, pronoids)
Ginkgo biloba, kuphela kwezilwanyana eziphilayo kwintsapho ye-Ginkgo, idla ngokubizwa ngokuba yi-Fessil. " Amagqabi ayo kunye nembewu yakhe isetyenziswa rhoqo kuPhando lwePhemacoboogical kwaye ngomnye wamayeza asetyenziswa kakhulu kwindalo kwihlabathi liphela. Iikhomputha ezisebenzayo kwi-Ginkgo e-Ginkgo e-Flavoids kunye nee-genoids, ezinazo iziphumo zokunciphisa i-liipid, i-antioxididants, i-scovidant yeliso, kunye nokubonelela ngomonakalo we-scalw yekhemikhali.
Imonograph yeHlabathi yeHlabathi yeHlabathi kwizityalo ze-Meshinoal ichaza ukuba kumiselwe umgangathoginkgoAmagqabi amagqabi kufuneka abe ne-22-27% ye-flavonosid ye-gelycossides kunye ne-5-7% ye-tepenoids, kunye nomxholo we-ginkgolic acid ngaphantsi kwe-5 mg / kg. EJapan, umbutho wokutya wezempilo usete imigangatho esemgangathweni ye-Ginkgo e-Ginkgo, efuna umxholo we-gelycoded glycode ubuncinci obuyi-24%, kunye ne-ginkgolic acid ephantsi kwe-5 ye-GPM. Ukuthathwa kwemihla ngemihla kuyacetyiswa kubantu abadala phakathi kwe-60 ne-240 mg.
Izifundo zibonakalise ukuba ukusetyenziswa kwexesha elide lokukhutshwa kwe-Ginkgo eMiselweyo, xa kuthelekiswa ne-placebo, kunokuphucula imisebenzi ethile yengqondo, kubandakanya ukuchaneka kwenkumbulo kunye nobulungisa. Ngaphezulu, ukukhutshwa kwe-ginkgo kuxeliwe ekuphuculeni ukuhamba kwegazi nobuchopho.
4. DHA
Dha. Ininzi into eyolwandlewa kunye neemveliso zabo, ngakumbi iintlanzi ezinamafutha, ezibonelela nge-0.68-1.3 I-GAMS ye-DHA nge-100 yeegram ezili-100. Ukutya okusekwe kwizilwanyana ezinjengamaqanda nenyama kuqukethe inani elincinci le-DHA. Ukongeza, ubisi lwebele lomntu kunye nolunye ubisi lwemibalabala lwe 'mammals lune-DHA. Uphando malunga ne-2 400 yabasetyhini kwizifundo ezingama-65 ezifunyenweyo ukuba i-DHA i-DHA i-0
I-DHA inxulunyaniswa nophuhliso lobuchopho, umsebenzi kunye nezifo. Uphando olubanzi lubonisa ukubaDhaInokomeleza i-neurotrons, ukukhula kwe-neronial, iplasitiki ye-synaptic, kunye nokukhutshwa kwe-neurotranston. Uhlalutyo lwe-meta olwenziwe ngokungacwangciswanga lubonise ukuba i-avareji yemihla ngemihla ye-580 mg ye-DHA iphucule inkumbulo ye-da ye-e-da ye-Apisodic ebalaseleyo kubantu abadala abasempilweni (18-90) kunye nabo babephantsi kwengqondo.
Iindlela ze-DHA zibandakanya: 1) Ukubuyisela umlinganiso we-N-3 / N-6; 2) ukunqanda ukwakhiwa kweminyaka yobudala obunxulumene nobudala obubangelwe yi-M1 yeseli yeseli ye-microglial; 3) Ukucinezela i-A1 I-A1 Asstracyte Phenotyte ngokunciphisa abamakishi abangafaniyo ne-C3 kunye ne-S100B; I-4) ethintela ngokufanelekileyo i-Potddnf / P75 uphawu lokusayina ngaphandle kokutshintsha i-neurotrophic ye-Kinase ye-Binese B. kunye ne-5) Ukukhuthaza ukusinda kwe-neuronal ngokwanda kwamanqanaba e-phosppheleridlselloserline, eququzelela iProtein Kinase B (AKT) yokuhambisa i-membrane yokuhambisa kunye nokusebenza.
I-5. I-Bifidobacterium McC1274
I-Gut, idla ngokubizwa ngokuba 'yingqondo yesibini, "ibonisiwe ukuba ibenayo indlela ebalulekileyo nengqondo. I-Gut, njengelungu elinombutho oshukumayo, ungasebenza ngokuzimeleyo ngaphandle kokufundiswa kwengqondo. Nangona kunjalo, unxibelelwano phakathi kwe-Gut kunye nengqondo lugcinwa kwinkqubo ye-automic nevaring, imiqondiso yehormonial, kunye neeCytokines, zenza oko kwaziwa ngokuba "
Uphando luveze ukuba i-Gut Bacteria idlala indima ekuqokeleleni iprotein ye-β-amyloid, umphawu ongumphawu ophambili kwi-Alzheimer's isifo sika-Alzheimer kwisifo sika-Alzheimer kwisifo sika-Alzheimer kwisifo sika-Alzheimer kwisifo sika-Alzheimer kwisifo sika-Alzheimer kwisifo sika-Alzheimer kwi-Alzheimer's. Xa kuthelekiswa nolawulo olusempilweni, izigulana zika-Alzheimer ziye zanciphisa ukwahluka kwe-Gut Microbiota, ngokuhla kwe-bificobacterium.
Kwizifundo zongenelelo kungenelelo kubantu abanobungozi bokuthobeka kwengqondo Amanqaku kwiindawo ezifana nememori, obonakalayo-obonakalayo ongenasiseko, ukuqhubekeka okunzima, kunye nememori encomekayo nayo iphuculwe kakhulu.
IXESHA LOKUQALA: UJAN-07-2025