Izimo zengqondo zabathengi malunga nokwaluphala ziyakhula. Ngokwengxelo yeentsingiselo zabathengi ngoUmthengi OmtshakwayeI-Coefficient Capital, abantu baseMerika abangakumbi abajolisanga nje ukuphila ixesha elide kodwa nokuphila ubomi obusempilweni.
Uphando lwe-2024 olwenziwe nguMcKinsey lubonise ukuba kunyaka odlulileyo, i-70% yabathengi base-US nase-UK (kunye ne-85% e-China) bathenge iimveliso kunye neenkonzo ezixhasa ukuguga okunempilo kunye nokuphila ixesha elide xa kuthelekiswa neminyaka edlulileyo. Olu tshintsho lubonisa umnqweno okhulayo wabathengi wokuthatha ulawulo olukhulu kwimpilo yabo.
Ukongeza,Ijenali yoShishino lweSondlo(NBJ) Ingxelo ye-2024 Longevity ibonisa ukuba ukususela ngo-2022, ukukhula kwentengiso kwinqanaba lokuguga elinempilo liye lahlala lidlula imarike yezongezo ezibanzi. Ngo-2023, ishishini lezongezelelo lilonke likhule nge-4.4%, ngelixa icandelo lokuguga elisempilweni lifumene i-5.5% yokukhula.NBJIiprojekthi zokuthengisa izongezo zokuguga ezinempilo-ezithatha amacandelo ahlukeneyo ajongene nemeko-ziya kudlula i-1 yeebhiliyoni zeedola ngo-2024 kwaye zifike kwi-1.04 yeebhiliyoni zeedola ngo-2026, ezimele izinga lokukhula kwe-7.7%.
Iinkxalabo zabathengi malunga neMiba yeMpilo eNxulumene nobudala
AnNBJUphando olwenziwe ngo-2024 luphonononge iinkxalabo zabathengi ezinxulumene nokuguga. Imiba ephambili iqukiwe:
Ukulahleka kokuhamba (28%)
Isifo sika-Alzheimer okanye isifo sengqondo esixhalabisayo (23%)
Ilahleko yombono (23%)
Ukuphulukana nokuzimela (19%)
Imingeni yempilo yengqondo okanye yengqondo (19%)
Ukuwohloka kwezihlunu okanye kwamathambo (19%)
Ukulahleka kweenwele (16%)
Ukuphuthelwa (16%)
Umthombo womfanekiso: NBJ
Xa usebenzisa izongezelelo, ukungakhuseleki (35%) kwavela njengeyona nto ibalulekileyo yempilo enxulumene nobudala kubathengi. Ezinye izinto eziphambili zibandakanya amathumbu kunye nempilo yokugaya (28%), impilo yokulala (23%), iinwele, ulusu, kunye nezipikili (22%), imisipha kunye nempilo edibeneyo (21%), impilo yentliziyo (19%), kunye nempilo yengqondo (19%).
Umthombo womfanekiso: NBJ
Izithako eziNhlanu zokuLwa nokuguga
1. Ergothioneine
I-Ergothioneine yi-amino acid eyenzeka ngokwemvelo efunyenwe ngo-1909 nguCharles Tanret ngelixa wayefunda i-ergot fungi. I-thiol yayo ekhethekileyo kunye ne-thione tautomerism kwi-pH ye-physiological inika iipropati ezikhethekileyo ze-antioxidant. Ngokwedatha evela kwi-Bloomage Biotech, i-ergothioneine kwi-Bioyouth™-EGT ibonisa umsebenzi we-DPPH wasimahla wokutshabalalisa ngokuphindaphindiweyo amaxesha ali-14 e-glutathione kunye namaxesha angama-30 e-coenzyme Q10.
Izibonelelo:
Ulusu:I-Ergothioneine ikhusela ukuvuvukala okubangelwa yi-UV, ikhusela umonakalo we-DNA, kwaye ikhuthaza i-collagen synthesis ngelixa inciphisa ukuchithwa kwe-collagen ehambelana ne-UV.
Ubuchopho:I-Ergothioneine isekela umsebenzi wokuqonda, njengoko kuboniswe ngophando lweklinikhi olubonisa ukuqonda okuphuculweyo emva kweeveki ze-12 zokuncedisa nge-ergothioneine ephuma kwi-mushroom.
Lala:Iwela umqobo wegazi-ingqondo, inciphisa ukubunjwa kwe-peroxynitrite, kwaye inciphise uxinzelelo, ikhuthaze ukulala okungcono.
2. I-Spermidine
I-Spermidine, inxalenye yentsapho ye-polyamine, ifumaneka ngokubanzi kwizinto eziphilayo ezifana neebhaktheriya, ukungunda, izityalo kunye nezilwanyana. Imithombo yokutya eqhelekileyo iquka ingqolowa yengqolowa, iimbotyi zesoya, kunye namakhowa e-oyster ukumkani. Amanqanaba e-Spermidine ayancipha ngokuguga, kunye nemiphumo yokuchasana nokuguga kubangelwa iindlela ezifana ne-autophagy induction, umsebenzi wokuchasana nokuvuvukala, kunye nokulawulwa kwe-lipid metabolism.
Iinkqubo:
I-Autophagy:I-Spermidine ikhuthaza iinkqubo zokuhlaziywa kweselula, ukujongana nezifo ezinxulumene neminyaka ezinxulumene neziphene ze-autophagy.
Ukuchasana nokudumba: Iyanciphisa i-cytokines e-pro-inflammatory ngelixa inyusa izinto ezichasayo.
IMetabolism yeLipid:I-Spermidine ichaphazela kakuhle i-lipid synthesis kunye nokugcinwa, ixhasa i-membrane yeselula fluidity kunye nokuphila ixesha elide.
3. IPyrroloquinoline Quinone (PQQ)
I-PQQ, i-quinone coenzyme enyibilikayo emanzini, ibalulekile kumsebenzi we-mitochondrial. Ikhusela kumonakalo we-mitochondrial oxidative, ikhuthaza i-mitochondrial biogenesis, kwaye ikhulise imveliso ye-nerve factor (NGF). Izifundo zeklinikhi zibonisa ukusebenza kwayo ekuphuculeni umsebenzi wokuqonda kunye nokuhamba kwegazi kwingingqi kubantu abadala.
4. Phosphatidylserine (PS)
I-PS i-anionic phospholipid kwiiseli ze-eukaryotic, ibalulekile kwiinkqubo ezifana nokusebenza kwe-enzyme, i-cell apoptosis, kunye nomsebenzi we-synaptic. Ethathwe kwimithombo efana neembotyi zesoya, izinto eziphilayo zaselwandle, kunye nojongilanga, i-PS ixhasa iinkqubo ze-neurotransmitter, kuquka i-acetylcholine kunye ne-dopamine, edibaniswa nempilo yokuqonda.
Usetyenziso:I-PS supplementation inxulunyaniswe nokuphuculwa kweemeko ezifana ne-Alzheimer's, isifo sikaParkinson, kunye nokudakumba, kwaye inceda abantu abane-ADHD kunye ne-autism spectrum disorders.
5. I-Urolithin A (UA)
UA, i-metabolite ye-ellagitannins efunyenwe kukutya okufana neerharnati kunye ne-walnuts, ichongiwe ngo-2005.Unyango Lwendalo(2016) ibonise ukuba i-UA ikhuthaza i-mitophagy, yandisa ubomi be-nematodes ngama-45%. Isebenzisa iindlela ze-autophagy ze-mitochondrial, icoca i-mitochondria eyonakeleyo kunye nokujongana nokungasebenzi kakuhle kwemisipha, intliziyo, i-immune kunye nempilo yesikhumba.
Indlela ye-mitophagy esebenzayo/Ireferensi yomthombo womfanekiso 1
Ukuqukumbela
Njengoko abathengi besanda ukubeka phambili impilo kunye nobomi obude, imfuno yezithako ezichasene nokuguga kunye nezongezo ziyaqhubeka nokukhula. Izithako eziphambili ezifana ne-ergothioneine, i-spermidine, i-PQQ, i-PS, kunye ne-UA zivula indlela yezisombululo ezijoliswe kuzo kwiinkxalabo ezinxulumene neminyaka. Ezi khompawundi zixhaswa ngokwenzululwazi zigxininisa ukuzibophelela kweshishini ekuxhaseni impilo, ukuguga okunamandla.
Ixesha lokuposa: Jan-08-2025