Ukutshintsha Iimbono Zabathengi Ngokwaluphala

Iimbono zabathengi malunga nokwaluphala ziyatshintsha. Ngokwengxelo yeendlela abathengi abaziphatha ngayoUmthengi OmtshakwayeI-Coefficient Capital, uninzi lwabantu baseMelika alujongi nje kuphela ubomi obude kodwa lujolisa nasekuphileni ubomi obusempilweni.

Uphando lukaMcKinsey lwango-2024 lutyhile ukuba kunyaka ophelileyo, ama-70% abathengi e-US nase-UK (kunye nama-85% e-China) bathenge iimveliso kunye neenkonzo ezingaphezulu ezixhasa ukwaluphala okunempilo kunye nokuphila ixesha elide xa kuthelekiswa neminyaka edlulileyo. Olu tshintsho lubonisa umnqweno okhulayo wabathengi wokulawula impilo yabo.

Ukongeza,Ijenali yeShishini lezondlo(I-NBJ) Ingxelo yoBude bexesha elide ka-2024 ibonisa ukuba ukusukela ngo-2022, ukukhula kwentengiso kudidi lokuguga okunempilo kuye kwadlula ngokuthe rhoqo imakethi ebanzi yezongezo. Ngo-2023, ishishini lezongezo lilonke likhule nge-4.4%, ngelixa udidi lokuguga okunempilo lufikelele kwizinga lokukhula le-5.5%.I-NBJiiprojekthi ezithengisaizongezo zokwaluphala ezisempilweni—equka iindidi ezahlukeneyo zeemeko ezithile—iza kudlula i-$1 billion ngo-2024 ize ifikelele kwi-$1.04 billion ngo-2026, nto leyo ebonisa izinga lokukhula kwe-7.7%.
1. Iinkxalabo zabathengi malunga nemiba yezempilo enxulumene nobudala

I-AnI-NBJuphando olwenziwe ngo-2024 luhlolisise iinkxalabo zabathengi ezinxulumene nokwaluphala. Imiba ephambili yayiquka:

Ukulahlekelwa kukuhambahamba (28%)
Isifo sika-Alzheimer okanye i-dementia (23%)
Ukulahleka kombono (23%)
Ukulahlekelwa kukuzimela (19%)
Imingeni yempilo yengqondo okanye yengqondo (19%)
Ukuwohloka kwemisipha okanye amathambo (19%)
Ukulahleka kweenwele (16%)
Ukungalali (16%)

Umthombo womfanekiso: NBJ

Xa usebenzisaizongezo, ukhuseleko lomzimba (35%) luvele njengeyona nto ibalulekileyo kwimpilo yabathengi enxulumene nobudala. Ezinye izinto eziza kuqala ziquka impilo yamathumbu kunye nokugaya ukutya (28%), impilo yokulala (23%), iinwele, ulusu, kunye neenzipho (22%), impilo yezihlunu namalungu (21%), impilo yentliziyo (19%), kunye nempilo-ntle yeemvakalelo (19%).

Umthombo womfanekiso: NBJ

2. Izithako Ezintlanu Eziphambili Zokulwa Nokwaluphala

1. I-Ergothioneine

I-Ergothioneine yi-amino acid yendalo eyafunyanwa ngo-1909 nguCharles Tanret ngelixa wayefunda nge-ergot fungi. I-thiol yayo ekhethekileyo kunye ne-thione tautomerism kwi-pH ye-physiological iyenza ibe neempawu ezibalaseleyo ze-antioxidant. Ngokwedatha evela kwiBloomage Biotech, i-ergothioneine kwi-Bioyouth™-EGT ibonisa umsebenzi wokususa ii-free radicals ze-DPPH ngokuphindwe ka-14 kune-glutathione kunye nokuphindwe ka-30 kune-coenzyme Q10.

Iingenelo:

Ulusu:I-Ergothioneine ikhusela ekuvuvukeni okubangelwa yi-UV, ithintela umonakalo we-DNA, kwaye ikhuthaza ukwenziwa kwe-collagen ngelixa inciphisa ukonakala kwe-collagen enxulumene ne-UV.
Ingqondo:I-Ergothioneine ixhasa ukusebenza kwengqondo, njengoko kuboniswe luphando lweklinikhi olubonisa ukuphuculwa kwengqondo emva kweeveki ezili-12 zokongezwa nge-ergothioneine ephuma kwikhowa.
Ukulala:Inqumla umqobo wegazi-ubuchopho, inciphisa ukwakheka kwe-peroxynitrite, kwaye inciphisa uxinzelelo, ikhuthaza ubuthongo obungcono.

2. I-Spermidine

I-Spermidine, eyinxalenye yosapho lwe-polyamine, ifumaneka kakhulu kwizinto eziphilayo ezifana neebhaktheriya, iifungi, izityalo, kunye nezilwanyana. Imithombo yokutya eqhelekileyo ibandakanya i-wheat germ, iisoya, kunye nee-king oyster mushrooms. Amanqanaba e-Spermidine ayehla ngokukhula, kwaye iziphumo zayo zokulwa nokwaluphala zibangelwa ziindlela ezifana nokungenisa i-autophagy, umsebenzi wokulwa nokuvuvukala, kunye nokulawulwa kwe-lipid metabolism.

Iindlela:

I-Autophagy:I-Spermidine ikhuthaza iinkqubo zokuphinda kusetyenziswe iiseli, ijongana nezifo ezinxulumene nokwaluphala ezinxulumene neziphene ze-autophagy.
Ukuchasa ukudumba: Iyanciphisa ii-cytokines ezibangela ukudumba ngelixa inyusa izinto ezilwa nokudumba.
I-Lipid Metabolism:I-Spermidine inefuthe elihle ekuhlanganisweni nasekugcinweni kwamafutha, ixhasa ukugeleza kwe-membrane yeseli kunye nobomi obude.

3. I-Pyrroloquinoline Quinone (PQQ)

I-PQQ, i-quinone coenzyme enyibilikayo emanzini, ibalulekile ekusebenzeni kwe-mitochondrial. Ikhusela ekonakaleni kwe-mitochondrial okubangelwa luxinzelelo lwe-oxidative, ikhuthaza i-mitochondrial biogenesis, kwaye iphucula ukuveliswa kwe-nerve growth factor (NGF). Izifundo zeklinikhi zibonisa ukusebenza kwayo ekuphuculeni ukusebenza kwengqondo kunye nokuhamba kwegazi kwengingqi kubantu abadala.

4. I-Phosphatidylserine (PS)

I-PS yi-anionic phospholipid kwi-membranes yeseli ye-eukaryotic, eyimfuneko kwiinkqubo ezifana nokusebenza kwe-enzyme, i-cell apoptosis, kunye nomsebenzi we-synaptic. Ivela kwimithombo efana ne-soya, izinto eziphilayo zaselwandle, kunye ne-sunflower, i-PS ixhasa iinkqubo ze-neurotransmitter, kubandakanya i-acetylcholine kunye ne-dopamine, ezidibene nempilo yengqondo.

Izicelo:Ukongezwa kwe-PS kuye kwanxulunyaniswa nokuphuculwa kweemeko ezifana ne-Alzheimer's, isifo sikaParkinson, kunye nokudakumba, kwaye kunceda abantu abane-ADHD kunye neengxaki ze-autism spectrum.

5. I-Urolithin A(UA)

I-UA, i-metabolite ye-ellagitannins efumaneka ekutyeni okufana neepomegranate kunye nee-walnuts, yachongwa ngo-2005. Uphando lwapapashwa kwiAmayeza endalo(2016) ibonise ukuba i-UA ikhuthaza i-mitophagy, yandisa ubomi be-nematodes nge-45%. Ivuselela iindlela ze-mitochondrial autophagy, isusa i-mitochondria eyonakeleyo kwaye ijongane nokungasebenzi kakuhle okunxulumene nobudala kwimisipha, kwintliziyo, kwi-immune, nakwimpilo yolusu.

Indlela ye-mitophagy esebenzayo ye-UA/Isalathiso somthombo womfanekiso 1

Isiphelo

Njengoko abathengi bebeka phambili impilo nobomi obude, imfuno yezithako ezintsha zokulwa nokwaluphala kunye nezongezo iyaqhubeka nokukhula. Izithako eziphambili ezifana ne-ergothioneine, i-spermidine, i-PQQ, i-PS, kunye ne-UA zivula indlela yezisombululo ezijoliswe kuzo kwiinkxalabo ezinxulumene nokwaluphala. Ezi khompawundi zixhaswa yisayensi zigxininisa ukuzinikela kweshishini ekuxhaseni ukwaluphala okunempilo nokunempilo ngakumbi.